, … 1 H NMR spectrum of 2M Ibuprofen taken with a single scan. 1. Ibuprofen, USP is a non-steroidal anti-inflammatory drug often used to treat and reduce fevers and swelling. 2(A)], the transmittance band of the carbonyl group at 1710 cm"', and also the characteristic finger printing of the disubstituted aromatic hydrocar- bons. Label the important peaks on your spectrum and in your table. The quantification of ibuprofen through infrared spectroscopy was developed and validated for pharmaceuticals in tablet form. Spectroscopy of polymer/drug formulations processed with supercritical fluids: in situ ATR-IR and Raman study of impregnation of ibuprofen into PVP Int. The IR spectrum shows the characteristic peaks of Ibuprofen indicating that the drug retains its identity in the formulation. (Spectra offset for clarity). Infrared Spectrum: Authentic: Boiling Point: 157.0°C (4.0 mmHg) Assay Percent Range: 99%: Linear Formula (CH 3) 2 CHCH 2 C 6 H 4 CH(CH 3)COOH: Merck Index: 15,4919: Solubility Information: Solubility in water: insoluble. 2. Thus the FTIR spectra ensure the presence of drug in each formulation. IR spectrum of pure Ibuprofen ( Figure 9 ) was identical with solid dispersions ( Figures 9-11 ). IR spectra (B) of (i) ibuprofen sodium salt powder and (ii) surface-enhanced IR spectrum of sodium ibuprofenate (50 mM) adsorbed onto Au nanoshells (inset shows high frequency regime). Figure 2 shows the 13 C spectrum collected with 12 scans in one minute, containing nine resonance signals with varying intensity. Make a data table for your IR. ibuprofen. If you were to take an IR of the wet product, what peaks would you see in the spectrum, and where would they show up on the spectrum? Compound Ibuprofenwith free spectra: 4 NMR, 6 FTIR, 1 Raman, and 24 MS. 13 C Spectrum of Ibuprofen. The carbons without a directly bonded proton (C2, C4, and C7) are represented by weak signals (181.5, 140.7, and 137.0ppm). All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 2 Figure 1. Ibuprofen, USP is a non-steroidal anti-inflammatory drug often used to treat and reduce fevers and swelling. The method involves the extraction of the active ingredient with chloroform and the measurement of the area of the infrared band corresponding to the carbonyl group centered at 1721.5 cm -1 . Be sure to signify the functional group corresponding to each wavenumber. H NMR spectrum of 2M Ibuprofen taken with a single scan C Spectrum of Ibuprofen It took one minute (12 scans) to obtain the 13C spectrum, which has … J. Pharm. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities. The quantification of ibuprofen through infrared spectroscopy was developed and validated for pharmaceuticals in tablet form. RESULTS AND DISCUSSION FT IR spectrum of Ibuprofen The FT-IR spectrum of disks of Ibuprofen standards diluted in potassium bromide exhibits acid bands around 3000 cm-' [see Fig.