Dr. Zhao’s laboratory in the Experimental Radiation Oncology (ERO) department is interested in the functional genomics of prostate cancers with two primary directives: (1) understanding how oncogenic signaling pathways and tumor microenvironment regulate cancer development and metastasis, and (2) searching for biomarkers and context-specific therapeutic targets for personalized cancer medicine. We performed a literature review of current evidence surrounding SARS‐CoV‐2 diagnostic testing highlighting its utility, limitations, and implications for otolaryngologists. It found sensitivities among radiologists to be between 73%‐93% and specificities to be between 93%‐100%.26 At this time, however, the majority of radiology societies do not recommend routine screening for COVID‐19 with chest CT.27, Testing of IgM and IgG specific antibodies to SARS‐CoV‐2 is done readily by obtaining blood samples and does not require specialized PCR equipment. A novel coronavirus was isolated as the causative agent. The data presented here rely primarily on early studies with confounders that can influence interpretation. The genome of this novel coronavirus is a single‐stranded positive‐sense RNA (+ssRNA). Cancer Discov. Zhao, X. et al. For patients who test positive for COVID‐19, the CDC has recommended that these patients be quarantined for at least 7 days and be asymptomatic with two negative PCR results done 24 hours apart to confirm clearance of SARS‐CoV‐2.33 New evidence has emerged suggesting that performing elective surgery on patients with COVID‐19 carries high risk of patient morbidity. However, for patients who undergo AGPs, the impact of a false negative result has serious implications to health care providers and other patients in the hospital. A total of 13 (32%) patients were admitted to the ICU and 6 (15%) patients died.9 A subsequent report of 138 patients, also from Wuhan, found that 98.6% of patients had fever, 69.6% had fatigue, and 59.4% dry cough. Qing Yi, MD, PhD is a Ralph O’Connor Centennial Chair, Cancer Center at Houston Methodist and Weill Cornell Medical College - specializing in Cancer immunotherapy, Hematological malignancies, Myeloma, Cancer biology. 2020 Jun 23;22(1):69. Xiao-qing ZHAO, Dermatologist, Dermatopathologist of Shanghai Ruijin Hospital, Shanghai (RJH) | Read 19 publications | Contact Xiao-qing ZHAO Use the link below to share a full-text version of this article with your friends and colleagues. Finally, to add further complexity to diagnosis, there may be variable viral load and shedding over time, even when the patient is asymptomatic. ‪MD Anderson Cancer Center‬ - ‪‪Cited by 56‬‬ ... Y Jiang, X Zhao, Q Xiao, Q Liu, K Ding, F Yu, R Zhang, T Zhu, G Ge. Your gift will help support our mission to end cancer and make a difference in the lives of our patients. An initial study on the kinetics of antibody formation found that of 535 patients, the total seroconversion rate for total Ab, IgM, and IgG was 93.1%, 82.7%, and 64.7%, with median seroconversion time of 11, 12, and 14 days.28 The same authors reported that combining RT‐PCR and antibody detection can improve the sensitivity for diagnosis of COVID‐19.28, A patient with a positive serologic test, however, only means that they have been exposed to SARS‐CoV‐2. Please check your email for instructions on resetting your password. Articles 1–2. Other names that Charlene uses includes Xiaojing C Zhao, Xiaojing V Chen, Charlene X Zhao, Charlene Xiaojing Zhao and Xiao J Zhao. 6/1/2019-5/31/2024 It has been named by the World Health Organization (WHO) as the severe acute respiratory distress syndrome coronavirus 2 (SARS‐CoV‐2) which causes the coronavirus disease 2019 (COVID‐19). Get the latest information on our cancer breakthroughs. Working off-campus? author = "Xiao Huang and Qingqing Ding and Hua Guo and Yun Gong and Jun Zhao and Min Zhao and Dawen Sui and Yun Wu and Hui Chen and Hui Liu and Jinxia Zhang and Erika Resetkova and Moulder, {Stacy L.} and Wang, {Wei Lien} and Lei Huo", Of note, new information on the COVID‐19 pandemic is being published at a fast rate. If you do not receive an email within 10 minutes, your email address may not be registered, Zhong Xi Yi Jie He Xue Bao. Testing for SARS‐CoV‐2 is important for decision making prior to surgery in otolaryngology. , Cai L, Lu X, Liang X, Li J, Chen P, Ittmann MM, Shang X, Jiang S, Li H, Meng C, Flores I, Song JH, Horner JW, Lan Z, Wu CJ, Li J, Chang Q, Chen KC, Wang G, Deng P, Spring DJ, Wang YA, DePinho RA. Email: xzhao6@mdanderson.org. A plausible explanation is that SARS‐CoV‐2 binds to human angiotensin‐converting enzyme 2 (ACE2), found predominantly in the lower respiratory tract.23 However, a potential confounder is that invasive lower respiratory tract sampling would be primarily performed on patients that have been intubated, which suggests that these patients overall may have higher viral load. Currently the CDC states that a negative result does not exclude SARS‐CoV‐2 infection. Chromatin Regulator, CHD1, Remodels Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer. Z7.4018 6565 MD Anderson Blvd Unit 1052 Houston, TX 77030, Contact Dr. Zhao: P: 713-792-7328 | In this article, we will review the current testing standards for COVID‐19 and discuss their strengths and limitations. Zhao’s return to China fits an ... Xiao … 9/1/2020-8/31/2021 The University of Texas MD Anderson Cancer Center: Poster Finalist for ... Wang L, Xiao Z, Yue Z, Zhao H, Fan Z, Zhao M, He F, Dai S, Qiu B, Yao J, Lin Q, Dong X*, Liu F. Efficacy of covered and bare stent in TIPS for cirrhotic portal hypertension: A single-center randomized trial. Xiao Zhao 1 2 3 , Jennifer Yin Yee Kwan 2 4 5 , Kenneth Yip 6 , Peter P Liu 7 , Fei-Fei Liu 8 ... University of Texas MD Anderson Cancer Center, Houston, TX, USA. Currently, there is no gold standard for the diagnosis of SARS‐CoV‐2. Special Issue: COVID‐19 VERSUS CANCER: Impact on Head and Neck Oncology Part 2. Dyspnea developed in 55% of patients with progression to ARDS in 29% of patients. She earned her PhD degree from the University of Texas MD Anderson Cancer Center in 2013. The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. As such, while serologic testing is important in the setting of confirming SARS‐CoV‐2 infection, this test does not indicate whether the patient is or is not actively infectious and shedding the virus. Specialized Programs of Research Excellence (SPORE) Grants, Prevention & Personalized Risk Assessment, Office of Clinical Research Administration, Comparative Effectiveness Training (CERTaIN), Post Graduate Fellowship in Oncology Nursing, Argyros Postdoctoral Research Fellowship in Oncology Nursing, Professional Student Nurse Extern Programs. As such even for patients tested negative for COVID19, many institutions suggest that the highest level of PPE available should be worn that protects against potential transmission of aerosolized SARS‐CoV‐2 for procedures of the upper aerodigestive tract. We find that concomitant removal of Ube2n , encoding the … The authors declare no potential conflict of interests. The FDA has also approved an EUA for multiple other commercial entities and academic medical centers to offer molecular testing either modified from the CDC protocol or developed with unique primers.18 RT‐PCR testing by other countries has targeted other sequences of the SARS‐CoV‐2 genome.19. Wang G, Zhao D, Spring DJ, DePinho RA. Until further research is done, the WHO does not currently recommend utilizing serologic testing to guide decision making.30. Early evidence suggests that the current standard for the diagnosis of SARS‐CoV‐2 using RT‐PCR has variations in sensitivity dependent on the subsite tested. The first report of 41 patients confirmed to have COVID‐19 in Wuhan, China found that initial symptoms included fever (98%), cough (76%), myalgia or fatigue (44%), sputum production (28%), headache (8%), hemoptysis (5%), and diarrhea (3%). Chest CT imaging for screening purposes is not currently recommended. Zhenna Xiao Student at The Univeristy of Texas MD Anderson Cancer Center Greater Houston. 2018 Sep 1;32(17-18):1105-1140, NIH/NCI Pathway to Independence Award (K99/R00) An inconclusive test occurs when only one segment is detected, and a negative test occurs when both segments are not detected. 2005;3: 378-381. Ming Xiao, a Kuei-jin of Chinese background, was the High Priestess of Chinatown, who operated from the Golden Temple, which was described by Gary Golden as a "cheap replica of Asian architecture better off in a theme park." There currently is no consensus on when PCR testing should be performed, and this is an area that needs further study. For the past two decades, Dr. Yi's laboratory has been working on the following research: (1) characterizing myeloma- and tumor-specific T cells and … Whether the resulting antibodies confer immunity to the virus requires further study. MD Anderson Cancer Center, Houston, TX, USA Andrei Alekseev, Hiep Khong, Tenghui Chen, Aibo Wang & Roza Nurieva Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Houston • Handled diverse range of data types, … The current CDC test detects and amplifies two regions of the nucleoside coding genome, N1 and N2. Patients who test positive during screening should have their surgeries postponed if possible until asymptomatic and have tested negative for SARS‐CoV‐2. Prof Xiao-Jun Huang, Peking University, China Prof Peter E Huber, German Cancer Research Center, Germany Dr Milind Javle, The University of Texas MD Anderson Cancer Center, USA Yubin Kang, Medical University of South Carolina, USA Prof Dan S Kaufman, University of California-San Diego, USA Prof Won Seog WS Kim, Samsung Medical Center, South Korea Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis. 24: An understanding of current and developing testing methods is important for interpreting test results. 24: 2014: The system can't perform the operation now. Metabolism 1 , 147–157 (2019). This study aims to analyze the expression and clinicopathological significance of SCF and HIF-1α in PDAC specimens and explore the molecular mechanism at PDAC cells in vitro and in vivo. We show that the transcriptional regulator STAT3 has an intrinsic protective role in the hematopoietic system, which is necessary to preserve HSPCs and lineage-balanced hematopoiesis. Sarcomatoid carcinoma of unknown primary (SCUP) is a rare entity of either poorly differentiated carcinoma with sarcoma-like differentiation or a true mixed lineage neoplasm. As there is no current gold standard for SARS‐CoV‐2 testing, careful re‐evaluation of the published evidence over time will be imperative. There are reports showing that patients who developed COVID‐19 and then resolved with negative serial PCR testing later again became positive on PCR assay.29 This could potentially represent a false positive result, or a viral carrier state despite a measured serologic conversion. Of 34 patients who underwent elective surgeries and subsequently became positive for COVID‐19, 44% required admission to the ICU and the mortality rate was 20.5%.34 As such, all patients with confirmed COVID‐19 should be discussed within a multidisciplinary team and surgery deferred, if possible, until proof of virus clearance is obtained and the patient is asymptomatic. Inflammation degrades hematopoietic stem and progenitor (HSPC) function, leading to myeloid-skewing and bone marrow failure. … The currently accepted RT‐PCR test for SARS‐CoV‐2 has varying sensitivity according to which subsite of the aerodigestive tract is sampled. Xiao Zhao, Department of Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX. Until more data is available, self‐administered testing has not been established as an adequate alternative to testing performed by a health care provider. As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. SARS‐CoV‐2 has spread rapidly across the world and by March 11th, 2020, the WHO officially declared the outbreak a pandemic.1 This pandemic has resulted in unprecedented challenges to the health care system and to society as a whole. Finally, it is imperative to point out once again the evidence on the COVID‐19 pandemic is rapidly evolving. 2020 May 8; CD-19-1352. The University of Texas Health Science Center MD Anderson Cancer Center, Graduate School of Biomedical Sciences, Houston, TX, USA ... Zhao Y, Varn F, Cai G, Xiao F, Amos CI, and Cheng C. A P53-deficiency gene signature predicts recurrence risk of patients with early stage lung adenocarcinoma. Routine endoscopic examinations including nasal endoscopy, flexible laryngoscopy as well as the use of energy devices during surgery are considered aerosol generating procedures (AGPs) with high risk for transmission.2 An analysis of 138 patients hospitalized with COVID‐19 in Wuhan, China found that 40 (29%) were health care workers.3 In fact, the first reported physician death associated with the disease was that of an otolaryngologist in Wuhan.4 In recognition of these risks and to conserve limited resources, the American Academy of Otolaryngology‐Head and Neck Surgery has recommended only performing procedures or surgeries that are time sensitive or emergent.5 Similar recommendations have been made by the American College of Surgeons as well as the Centers for Medicare and Medicaid Services (CMS).6, 7 In an effort to reduce risk, many professional societies have recommended screening for COVID‐19 prior to high‐risk procedures as emerging data suggests that patients can be asymptomatic carriers.2, 8. Learn about our graduate medical education residency and fellowship opportunities. S100A10 is a critical mediator of GAS6/AXL-induced angiogenesis in renal cell carcinoma Authors: Y Xiao, H Zhao, L Tian, R Nolley, AN Diep, A Ernst, KC Fuh, YR Miao, R von Eyben, JT Leppert, JD Brooks, DM Peehl, AJ Giaccia, EB Rankin Cancer Res., 2019;0(0):. Upper respiratory type symptoms were relatively infrequent with only 13.9% presenting with sore throat and 4.8% of patients with nasal congestion. Choose from 12 allied health programs at School of Health Professions. In December of 2019, an outbreak of patients with severe pneumonia was reported in Wuhan, China. As such, many institutions have recommended that all personnel at risk for exposure to aerosolization of SARS‐CoV‐2 wear full personal protective equipment. Try again later. doi: 10.1158/2159-8290. Office: Z7.3028 Email: Dzhao2@mdanderson.org, © 2021 The University of Texas MD Anderson Cancer Center. 9/14/2018-8/31/2023 Xiao Zhao, Department of Otolarynglogy, University of Toronto, Toronto, Ontario, Canada. Daniel B Vinh 1 , Xiao Zhao 2 , Kimberley L Kiong 2 , Theresa Guo 2 , Yelda Jozaghi 2 , Chris Yao 2 , James M Kelley 3 , Ehab ... MD Anderson Cancer Center, Houston, Texas, USA. View Yiqun Zhao’s profile on LinkedIn, ... Zhenna Xiao. Since joining MD Anderson, Dr. Xia has focused on cancer metabolism research. Sources of false negative testing include patient misidentification, collection of inappropriate or inadequate material, improper specimen transportation, low viral density in presymptomatic patients, and lab errors. Ming Xiao is highly diplomatic a… Principal Investigator, Lab location: Zayed Building Google Scholar | Crossref | Medline Summary: You's current home is located at Rockville, MD. Journal of molecular cell biology 6 (4), 352-354, 2014. RNA primers for amplification and detection of these genetic segments are available publicly on the CDC web site.16 Internal testing by the CDC comparing these primers and probes for N1 and N2 against public domain nucleotide sequences found no significant homologies with the human genome, other coronaviruses, or human microflora that would lead to a potential false positive.17 Limits of detection by RT‐PCR were also tested internally by the CDC. As such, the presence of antibodies does not necessarily reflect a person's potential to transmit the disease. Her work on understanding the roles of PKM2, PGK1, KHK-A in Warburg effect and tumorigenesis and novel identification of these metabolic enzymes as protein kinases have been published on top journals. Log in to our secure, personalized website to manage your care (formerly myMDAnderson). Statistical Analyst MD Anderson Cancer Center September 2013 – January 2018 4 years 5 months. Genetics and Biology of Prostate Cancer. ... Y Jiang, X Zhao, Q Xiao, Q Liu, K Ding, F Yu, R Zhang, T Zhu, G Ge. Zhao, H, Zhao, A, You, S. Growth-inhibiting and anti-metastasis effects of Weichang’an Decoction on orthotopic transplant nude mouse model of human gastric cancer [in Chinese]. https://www.polyu.edu.hk/bme/people/academic-staff/dr-xin-zhao In a study of 213 patients with confirmed COVID‐19, the authors found that sputum samples showed the highest positive rate in both severe (88.9%) and mild (82.2%) cases, followed by nasal swabs (73.3%, 72.1%), and then throat swabs (60.0%, 61.3%).21 In a similar study consisting of 205 patients, Wang et al found that bronchoalveolar lavage had the highest positive rates (93%), followed by sputum (72%), nasal swabs (63%), bronchoscope brushings (46%), pharyngeal swabs (32%), feces (29%), and blood (1%).22 From these studies, it appears that the highest positive detection rate is from lower respiratory tract specimens. Find Dr. Zhao's phone number, address, hospital affiliations and more. 17 Patterns of neck nodal metastases and recurrence in human papilloma virus-associated ... Texas MD Anderson Cancer Center, Houston, Texas, United States. Guo H*, Ding Q*, Gong Y, Gilcrease MZ, Zhao M, Zhao J, Sui D, Wu Y, Chen H, Liu H, Zhang J, Resetkova E, Moulder SL, Wang WL, Huo L. Comparison of three scoring methods using the FDA-approved 22C3 immunohistochemistry assay to evaluate PD-L1 expression in breast cancer and their association with clinicopathologic factors.Breast Cancer Res. and you may need to create a new Wiley Online Library account. She was well acquainted with Chinatown's prominent people such as Wong Ho, a respected businessman. Due to the current sensitivity of RT‐PCR based testing for SARS‐CoV‐2, a negative test cannot rule out COVID‐19. This would include N95 or powered air purifying respirator (PAPR), even for asymptomatic patients with negative testing during this pandemic.4. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA, Antibody responses to SARS‐CoV‐2 in patients of novel coronavirus disease 2019, Positive RT‐PCR test results in patients recovered from COVID‐19, Early institutional head and neck oncologic and microvascular surgery practice patterns across the United States during the SARS‐CoV‐2 (COVID19) pandemic, Discontinuation of Isolation for Persons with COVID‐19 Not in Healthcare Settings (Interim Guidance), Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID‐19 infection, https://www.who.int/news-room/detail/08-04-2020-who-timeline–-covid-19, https://doi.org/10.1001/jamaoto.2020.0780, https://doi.org/10.1001/jamaoto.2020.0488, https://www.entnet.org/content/new‐recommendations‐regarding‐urgent‐and‐nonurgent‐patient‐care, https://www.facs.org/covid‐19/clinical‐guidance/elective‐surgery, https://www.cms.gov/files/document/cms‐non‐emergent‐elective‐medical‐recommendations.pdf, https://doi.org/10.1007/s00405-020-05965-1, https://doi.org/10.1101/2020.03.27.20043836, https://doi.org/10.2807/1560-7917.ES.2020.25.10.2000180, https://www.cdc.gov/coronavirus/2019‐ncov/lab/rt‐pcr‐panel‐primer‐probes.html, https://www.fda.gov/media/134922/download, https://www.fda.gov/emergency‐preparedness‐and‐response/mcm‐legal‐regulatory‐and‐policy‐framework/emergency‐use‐authorization, https://doi.org/10.1101/2020.02.25.964775, https://doi.org/10.1101/2020.02.11.20021493, https://doi.org/10.1148/radiol.2020200642, https://doi.org/10.1148/radiol.2020200823, https://www.who.int/news‐room/commentaries/detail/advice‐on‐the‐use‐of‐point‐of‐care‐immunodiagnostic‐tests‐for‐covid‐19#.XpM1L2aCbKI.email, https://www.cdc.gov/coronavirus/2019-nCoV/lab/guidelines-clinical-specimens.html, https://www.cdc.gov/coronavirus/2019-ncov/hcp/disposition-in-home-patients.html, https://doi.org/10.1016/j.eclinm.2020.100331.
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