You can get your natural intake of diindolylmethane if you include these healthy foods in your diet (x): When taken correctly in the small amounts found in foods, diindolymethane is likely safe. Web. One study analyzes the effect of DIM on 130 women with breast cancer over 12 months. However, signs are encouraging. The typical clinical trial uses between 150 and 300 mg of DIM, taken all at once. Part-time sports journalist covering the Vegas Golden Knights. Prabodh K. Kandala and Sanjay K. Srivastava Diindolylmethane-mediated Gli1 Protein Suppression Induces Anoikis in Ovarian Cancer Cells in Vitro and Blocks Tumor Formation Abilityin Vivo* J Biol Chem. Epub 2013 Apr 29. DIM is a natural substance that is generated when the body breaks down indole-3-carbinol, which is found in certain vegetables, mainly those that are related to the cabbage family. This ultimately helps improve the process of breaking down estrogen (x). These include mood swings, irritability and anger, among others. Aids healthy hormone balance for men & women, Mitigates some effects of excess estrogen, Anti-oxidant & anti-inflammatory benefits. 2012 Jan 3; 106(1): 45–52. The appropriate amount for each individual will depend on a number of factors, including age, weight, prior medical conditions, and current medications. Get notified about exclusive offers every week! Gregory A. Reed, Jean M. Sunega, Debra K. Sullivan, John C. Gray, Matthew S. Mayo, James A. Crowell, and Aryeh Hurwitz Single-Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3, 3?-Diindolylmethane in Healthy Subjects Cancer Epidemiol Biomarkers Prev. 2008 Oct; 17(10): 2619–2624. Take DIM & D-Glucarate to favourably alter your production of estrogen metabolites. 20 to 50 milligrams of DHEA supplements are safe for people over the age of 30, according to the National Institute of Health. Cancer Biol Ther. Administration of 600 or more milligrams daily of DIM is considered to be possibly unsafe. Watercress. In some rare cases, gastrointestinal upset and/or headaches have been reported. To date, research on the health effects of diindolylmethane is fairly limited. Concerning breast cancer, diindolylmethane administration has demonstrated the following in research studies: In one 250-day murine study, spontaneous tumor growth was reduced by more than 45% following DIM administration. For men involved in a plan of muscular development and/or fat loss, the dose of DIM could be increased to 400 – 500mg per day. Different rat groups in this study were fed two different DIM dosages equivalent to 4.8mg/kg and 9.6mg/kg of bodyweight. During a normal menstrual cycle, levels of estrogen and progesterone normally oscillate between high and low levels. Carcinogenesis. Diindoylymethane (DIM) is a component of Indole-3-carbinol (I3C) found in members of the Brassica family. Remember, inositol is well tolerated so there isn't a risk of overdose here. DIM helps estrogen break down into the “good” kind. But did you know that diindolylmethane (also known as DIM) is one of the reasons the Brassica family of vegetables is considered so healthy (x)? Human studies, often at five times the typical supplement dose of DIM, have shown good tolerability. At the very least, one can naturally consume DIM through vegetables if supplementation isn’t an option. Although DIM supplements are sometimes touted as natural weight loss aids, there’s no scientific proof to support the claim that taking DIM promotes weight loss. The optimal dosage of DIM for various indications is unclear. A person’s age, health history and other conditions will determine the appropriate dosage. This effect was believed to be associated directly with an increase in estradiol 2-hydroxylation; an anti-estrogenic effect.
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